Azaris

AZARIS^®  IMUNO food supplement                     40 capsules

¹ SCIENTIFIC STUDIES

• Ox-knee- Achyranthes bidentata extract  ^{( 1,16,17,18 )}

• ABP has immunomodulatory effect by increasing the proliferation of T cells, increases immunity reaction,  influences the activity of osteoclasts  thereby reducing the loss of bone mass and structure, increases bone mineralization density and activation of osteoblasts. It helps with neurological damage.

• Black cumin – Nigella sativa extract ^{( 2,3,4,)}

• The main active substances thymoquinone and thymol acting antiviral, anti-inflammatory, antioxidant, immunomodulatory, anti-diabetic, anti-bacterial and reduces liver damage.

• Black elderberry – Sambucus nigra extract ^{( 7,8,9,10 )}

• Works immunomodulatory and antiviral against several types of viruses in particular influenza virus (influenza  A and B). With alpha linoleic, linoleic acid and the flavonoid naringenin affects peroxisome proliferator-activated receptor (PPAR) γ, reduces insulin resistance and reduces the occurrence of type 2 diabetes. Works as anti-parasitic especially against Taxoplasma gondii.

• Astragalus – Astragalus membranaceus extract ^{( 5,6 )}

• With the active substances of type IV astragaloside and its polysaccharides it has immunomodulatory effect and protects the immune system. It reduces the occurrence of common cold  and infection of the upper respiratory system. It acts as an antioxidant and reduces cell damage. It regulates the level of cholesterol and has beneficial effect on the cardiovascular system.

• Maitake mushroom – Grifola frondoza extract ^{( 11,12,13,15 )}

• Trough the main active substance beta-glucans  1.3 and its D-fraction, it has strong antivirus and immune stimulatory activity. Its action are mainly through the activation of T-cells and macrophages and has been shown activity against multiple cancer types. With its anti-inflammatory effect it also helps the prevention of  type 2 diabetes.

• Resveratrol – polygonum cuspidatum extract ^{( 14 )}

• A polyphenol present in several species of plants, but most of the grapes and, as such, in red wine. It has antioxidant and anti-inflammatory effect through the reduction of inflammation and inflammatory mediators, such as COX (cyclooxygenase 1 and 2) and reducing the synthesis of prostaglandins. The best effects on the immune system was demonstrated in small doses.

• Zinc

• The mineral most commonly found in meat , seafood , nuts and grains . It plays an important factor in maintaining good health and immunity.

Effect of Achyranthes bidentata polysaccharides (ABP) on antitumor activity and immune function.

Yu S, Zhang Y.

Zhonghua Zhong Liu Za Zhi. 1995 Jul;17(4):275-8. Chinese. ⁽¹⁾

Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs.

Boskabady MH, Keyhanmanesh R, Khameneh S, Doostdar Y, Khakzad MR.

J Zhejiang Univ Sci B. 2011 Mar;12(3):201-9. doi: 10.1631/jzus.B1000163. ⁽²⁾

Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects.

Amin B, Hosseinzadeh H.

Planta Med. 2015 Sep 14. [Epub ahead of print] ⁽³⁾

Evaluation of Antioxidant and Antibacterial Potentials of Nigella sativa L. Suspension Cultures under Elicitation.

Chaudhry H, Fatima N, Ahmad IZ.

Biomed Res Int. 2015;2015:708691. doi: 10.1155/2015/708691. Epub 2015 Aug 12. ⁽⁴⁾

Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells.

Lu Y, Li S, Wu H, Bian Z, Xu J, Gu C, Chen X, Yang D.

Int J Mol Med. 2015 Sep 15. doi: 10.3892/ijmm.2015.2345. [Epub ahead of print] ⁽⁵⁾

The antioxidant effects of Radix Astragali (Astragalus membranaceus and related species) in protecting tissues from injury and disease.

Shahzad M, Shabbir A, Wojcikowski K, Wohlmuth H, Gobe GC.

Curr Drug Targets. 2015 Sep 6. [Epub ahead of print] ⁽⁶⁾

Anti-Toxoplasma activities of methanolic extract of Sambucus nigra (Caprifoliaceae) fruits and leaves.

[No authors listed]

Rev Biol Trop. 2015 Mar;63(1):7-12. ⁽⁷⁾

Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama.

Zakay-Rones Z, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M.

J Altern Complement Med. 1995 Winter;1(4):361-9. ⁽⁸⁾

A systematic review on the sambuci fructus effect and efficacy profiles.

Vlachojannis JE, Cameron M, Chrubasik S.

Phytother Res. 2010 Jan;24(1):1-8. doi: 10.1002/ptr.2729. Review. ⁽⁹⁾

Anti-influenza virus effects of elderberry juice and its fractions.

Kinoshita E, Hayashi K, Katayama H, Hayashi T, Obata ABiosci Biotechnol Biochem. 2012;76(9):1633-8. Epub 2012 Sep 7. ⁽¹⁰⁾

Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function.

Chen YH, Lee CH, Hsu TH, Lo HC.

Int J Med Mushrooms. 2015;17(6):541-56. ⁽¹¹⁾

Immunomodulatory properties of Grifola frondosa in submerged culture.

Wu MJ, Cheng TL, Cheng SY, Lian TW, Wang L, Chiou SY.

J Agric Food Chem. 2006 Apr 19;54(8):2906-14. ⁽¹²⁾

Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients.

Kodama N, Komuta K, Nanba H.

J Med Food. 2003 Winter;6(4):371-7. ⁽¹³⁾

Resveratrol decreases oxidative burst capacity and alters stimulated leukocyte cytokine production in vitro.

Woode RA, Axiak-Bechtel SM, Tsuruta K, Amorim JR, Zhang Y, DeClue AE.

Vet Immunol Immunopathol. 2015 Feb 15;163(3-4):164-73. doi: 10.1016/j.vetimm.2014.12.004. Epub 2014 Dec 22. ⁽¹⁴⁾

Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts.

Vetvicka V, Vetvickova J.

Ann Transl Med. 2014 Feb;2(2):14. doi: 10.3978/j.issn.2305-5839.2014.01.05. ⁽¹⁵⁾

Antitumor activity and immuno-potentiating actions of Achyranthes bidentata polysaccharides.

Xiang DB, Li XY.

Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):556-61. ⁽¹⁶⁾

The Achyranthes bidentata polypeptide k fraction enhances neuronal growth in vitro and promotes peripheral nerve regeneration after crush injury in vivo.

Cheng Q, Jiang C, Wang C, Yu S, Zhang Q, Gu X, Ding F.

Neural Regen Res. 2014 Dec 15;9(24):2142-50. doi: 10.4103/1673-5374.147948. ⁽¹⁷⁾

Achyranthes bidentata saponins promote osteogenic differentiation of bone marrow stromal cells through the ERK MAPK signaling pathway.

He G, Guo W, Lou Z, Zhang H.

Cell Biochem Biophys. 2014 Sep;70(1):467-73. doi: 10.1007/s12013-014-9942-3. ⁽¹⁸⁾