• • Bioflavonoid most abundant in citrus fruits
• • It can inhibit the enzymes collagenase and elastase, thus contributing better synthesis of collagen and elastin.
• • It can create the preconditions for reduction of osteoclasts and thereby strengthens bone structure.
• • With a high content of bioactive hesperetin-7-glucoside.
• • It can contribute to strengthening  of blood vessel walls.

^{( 1  )} HESPERIDIN – through many scientific research has shown that it can help with:

• • Inflammatory processes  ^{( 1,7 )}
• • Osteoporosis and skeletal  inflammation  ^{( 9,10 )}
• • Oxidative stress  ^{( 1,6 )}
• • Prevention of cardiovascular diseases  ^{( 2,5,8,11 )}
• • Against the action of microbes and toxins  ^{( 3 )}
• • Hemorrhoids  and for internal hemorrhoids incurred during pregnancy  ^{( 5 )}
• • Neurological disorders  ^{( 4,7,8 )}

Antioxidant and antiinflammatory properties ofthe citrus flavonoids hesperidin and hesperetin: an updated review of theirmolecular mechanisms and experimental models.

Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M.

Phytother Res. 2015 Mar;29(3):323-31. doi: 10.1002/ptr.5256. Epub 2014 Nov 13. ⁽¹⁾

Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer andcardiovascular diseases.

Roohbakhsh A, Parhiz H, Soltani F, Rezaee R, Iranshahi M.

Life Sci. 2015 Mar 1;124:64-74. doi: 10.1016/j.lfs.2014.12.030. Epub 2015 Jan 24 ⁽²⁾

Protective effects of flavonoids against microbes and toxins:The cases of hesperidin and hesperetin. Iranshahi M, Rezaee R, Parhiz H, Roohbakhsh A, Soltani F.

Life Sci. 2015 Sep 15;137:125-32. doi: 10.1016/j.lfs.2015.07.014. Epub 2015 Jul 17. Review. ⁽³⁾
 
Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin–a mini-review.

Roohbakhsh A, Parhiz H, Soltani F, Rezaee R, Iranshahi M.

Life Sci. 2014 Sep 15;113(1-2):1-6. doi: 10.1016/j.lfs.2014.07.029. Epub 2014 Aug 7. ⁽⁴⁾

Micronized flavonoid therapy in internal hemorrhoids of pregnancy.

Buckshee K, Takkar D, Aggarwal N.

Int J Gynaecol Obstet. 1997 May;57(2):145-51. ⁽⁵⁾

Antioxidant activity of the flavonoid hesperidin in chemical and biological systems.

Wilmsen PK, Spada DS, Salvador M.

J Agric Food Chem. 2005 Jun 15;53(12):4757-61. ⁽⁶⁾

Health-promoting Effects of the Citrus Flavanone Hesperidin.

Li C, Schluesener H.

Crit Rev Food Sci Nutr. 2015 Feb 12:0. ⁽⁷⁾

Hesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia/reperfusion in a C57BL/J6 mouse model.

Oztanir MN, Ciftci O, Cetin A, Aladag MA.

Neurol Sci. 2014 Sep;35(9):1393-9. doi: 10.1007/s10072-014-1725-5. Epub 2014 Mar 28. ⁽⁸⁾

Prevention of osteoporosis by foods and dietary supplements. Hesperidin and bone metabolism.

Uehara M.

Clin Calcium. 2006 Oct;16(10):1669-76. Review. Japanese. ⁽⁹⁾

Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice.

Chiba H, Uehara M, Wu J, Wang X, Masuyama R, Suzuki K, Kanazawa K, Ishimi Y.

J Nutr. 2003 Jun;133(6):1892-7. ⁽¹⁰⁾

Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats.

Ikemura M, Sasaki Y, Giddings JC, Yamamoto J.

Phytother Res. 2012 Sep;26(9):1272-7. doi: 10.1002/ptr.3724. Epub 2012 Jan 7. ⁽¹¹⁾